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3D Cell Culture Systems to Enhance Cell Culture Results

Home - Technology - 3D Cell Culture Systems to Enhance Cell Culture Results

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Amerigo Scientific, a distributor focused on providing critical products and services to biomedical and life science communities, aims to enhance cell culture results by providing researchers and laboratories with a variety of simple and high-performance 3D cell culture systems. 

Three-dimensional (3D) cell culture provides an artificially created micro-environment for optimal cell growth, differentiation and function, and the ability to create tissue-like constructs in vitro. 3D cell culture allows individual cells to maintain their normal 3D shape, structure and function with minimal exogenous support and interference. Cells form complex interactions with adjacent cells and receive and transmit signals. 3D cell culture techniques reduce the gap between in vitro culture and the physiological environment. In vitro models based on 3D culture are closer to animal models in many aspects. And, assays using 3D-cultured cells are rapid, cost-effective, versatile, and easily reproducible compared to cost-intensive animal models. To meet the growing demand, various advanced 3D cell culture methods have been developed, which are generally divided into scaffold-based culture.

Scaffolds formed from natural and/or synthetic materials play an important role in constructing the artificial in vivo-like environment and inducing specific morphological and physiological behaviors of cultured cells. Scaffolds based on natural biomaterials such as collagen, hyaluronic acid, gelatin, and alginate are inherently biocompatible and bioactive with the myriad of endogenous factors. Synthetic scaffolds with a definite chemical composition can achieve reproducibility, inertia, non-degradability, and tunable degradability that are not possible in naturally derived biomaterials. In scaffold-based 3D cell culture systems, cells are seeded on scaffolds, where the cells attach and colonize. The spherical geometry closely resembles the structural and physiological environment of some tumor types, making it relatively easy to model dynamic processes of solid tumors. In addition, the integration of non-scaffold cell culture with microfluidics technology allows the biofabrication of more complex types of spheroids. Microfluidic technology also known as lab-on-a-chip (LOC) allows spatial control of fluids in micron-sized channels, and the application of this technology to 3D culture can improve the physiological relevance of 3D cell models.

3D cell culture provides an artificially created microenvironment to achieve optimal cell growth, differentiation, and function, as well as the ability to create tissue-like structures in vitro. Compared to costly animal models, assays using 3D-cultured cells are rapid, cost-effective, versatile, and easily reproducible. To date, 3D cell culture systems, including scaffold-based, have been widely applied in differentiation studies, drug discovery, cancer research, gene and protein expression studies, and cellular physiological studies.


Amerigo Scientific is committed to offering the latest advancements in laboratory technology to its customers. By integrating high-performance 3D cell culture systems such as SpherTantrix 3D scaffolds into its offerings, the company hopes to provide researchers with a comprehensive solution for studying cells in a more realistic and predictive manner.


The innovative 3D cell culture systems can offer a more physiologically relevant environment for studying cell behavior and interaction compared to traditional 2D cell culture models. By providing scientists with tools that better mimic the complex biological processes that occur in vivo, these products enable more accurate and reliable results in drug discovery, toxicology studies, and regenerative medicine research.


“We are excited to bring these cutting-edge 3D cell culture systems to our customers,” said the business development manager at Amerigo Scientific. “These advanced tools will empower researchers to conduct more robust experiments and gain deeper insights into cellular processes, leading to significant advancements in biomedical research.”


Amerigo Scientific is dedicated to advancing scientific knowledge and supporting researchers in their quest for discoveries. By expanding its product portfolio, the company is poised to make a meaningful impact on the field of cell culture and contribute to the development of innovative treatments and therapies.


About Amerigo Scientific

Amerigo Scientific, as a recognized distributor in the United States, collaborates closely with leading manufacturers worldwide and invites cooperation to all companies and institutions in the branch of reagents, kits, antibodies, and many other products for life science, biochemistry, and biotechnology. Its professional team is equipped with excellent technical support and thoughtful customer service. As most of its employees have earned a graduate (Ph.D. or M.S.) degree in life science, they can comprehend customers’ questions or concerns and are always ready to provide individualized customer service of high standards.